DISEASES OF CATTLE IN TODAY'S NEWS

While there is much misinformation being put forth regarding BSE, Dr. John Maas, Extension Veterinarian, provided the following information, which should help you be better informed about this disease. You can help others understand what it is and explain to others what is in place to prevent it from occurring in the United States.

Bovine Spongiform Encephalopathy: What Is Our Risk In America?
Bovine Spongiform Encephalopathy (BSE) or what the news media insist on calling "mad cow disease" has been recognized for almost 15 years as a devastating disease of cattle. There are still many questions regarding this disease. However, there has been some progress and more is known about the mysterious condition. A more important question is, "What are the risks of introducing BSE in the United States?"

What is Bovine Spongiform Encephalopathy (BSE)?
BSE is a chronic degenerative disease that affects the central nervous system (brain & spinal cord) of cattle, first diagnosed in cattle in Great Britain in 1986. BSE belongs to a group of diseases known as Transmissible Spongiform Encephalopathies (TSEs) These TSEs include scrapie (sheep & goats), transmissible mink encephalopathy, feline spongiform encephalopathy (cats), chronic wasting disease of elk and mule deer, and BSE in cattle. Humans have a number of TSEs also and these include kuru, Creutzfeldt Jakob Disease (CJD), new variant Creutzfeldt Jakob Disease (nvCJD), Fatal Familial Insomnia, Gerstmann-Straussler syndrome (in humans). The clinical signs or symptoms in cattle appear as nervousness or aggression, abnormal posture, incoordination, weight loss, difficulty rising, progressing to death. There is no treatment for any of these conditions, and currently there are no vaccines available for prevention.

How is BSE recognized or diagnosed?
BSE cannot be confirmed in the live animal. It has signs similar to rabies, polioencephalomalacia, Hemophilus somnus infection, and a number of other diseases. The microscopic examination of brain tissue is the only way BSE can currently be diagnosed. There is no "live animal test" for BSE; however, one is urgently needed. A live animal test that could identify an "infected" animal well before it becomes ill would be particularly valuable.

What causes BSE?
The cause of BSE and the other TSEs in other species is not fully understood. Most of the scientific community feels the cause is a prion or abnormal protein. BSE (like all TSEs) has (1) a long incubation period (most often several years), (2) is smaller than a typical virus, (3) the agent is resistant to sunlight, radiation, and common disinfectants, and (4) the agent causes no detectable immune response in the host.

Why did BSE occur in Great Britain and subsequently spread to Europe?
The bottom line to this question is "No one knows for sure." The epidemiologic data suggests that BSE is associated with the feeding of meat and bone meal as a protein source to dairy cattle and other cattle. The causative agent is suspected to have come from either scrapie-infected sheep or from cattle with a previously unknown TSE. Changes in the rendering practices in the U.K., such as lowering the temperature of processing and/or removing the solvent step in processing, may have allowed the survival of the agent in the meat and bone meal. BSE had never been identified before 1986, when it was first recognized in Britain. BSE has been confirmed in native cattle in Ireland, Northern Ireland, France, Portugal, Germany, and Switzerland. It is now thought that meat and bone meal exported from the U. K. was responsible for the infection of native cattle in these other countries. BSE has been identified in cattle exported from Britain to other countries. Prior to 1986, a small amount (14 tons) of ruminant protein was imported from the U.K. to the U.S.A. Our current regulations prohibit the import of ruminant proteins from any country affected with BSE. Overall, 99% of the BSE cases have occurred in the U. K. Currently, the BSE epidemic in Britain is winding down; however, cases of BSE have been identified at an alarming rate on mainland Europe.

Do we have BSE in the United States?
No. There have been no cases of BSE in the U.S.A. There was one case in Canada (which was in a cow imported from Britain). Before the ban on British cattle imports into the U.S.A. went into affect in 1989, there were 499 cattle brought to the U.S.A. from Britain. All of those cattle were carefully accounted for and none showed evidence of BSE. Veterinarians and others in the U.S.A. have very aggressive surveillance programs for BSE. This includes the National Veterinary Services Laboratory in Ames, Iowa, the Centers for Disease Control, the USDA, and all state veterinary diagnostic laboratories. Surveillance of high-risk populations, such as disabled dairy cattle, has continued at a high rate, with more than 1,000 cattle from California alone examined for evidence of BSE to date. So far, there has been no evidence of BSE in the U.S.A.

What else has been done to prevent BSE from occurring in the U.S.A.?
No beef or beef products, including items such as fetal bovine serum for use in research laboratories, have been imported from counties known to have BSE, such as Britain since 1989. Also, no beef products were imported from Britain to the U.S.A. prior to 1989 because no FSIS-approved establishments for export to the U.S.A. existed in the U.K. Current regulations prohibit the importation of ruminant protein from all countries affected with BSE. As mentioned above, surveillance is continuing at a very high rate.

Does BSE cause new variant Creutzfeldt Jakob Disease (nvCJD) in humans?
CJD is a slow progressive disease of humans that affects the central nervous system, causing dysfunction, progressive dementia, and death. CJD occurs throughout the world at a rate of about 1-2 cases per million people per year. There has been a major change in CJD in Britain since the outbreak of BSE in cattle. This change has been the recognition of a new variant CJD or nvCJD in humans. To date, there have been more than 70 cases of nvCJD recognized in humans in Britain and one case in France. The exact cause of this new form of the disease is not entirely known; however, circumstantial evidence suggests that BSE may be involved. It is this possibility that nvCJD could jump the "species boundary" from cattle to humans that has everyone so nervous. The abnormal protein in the brain of nvCJD patients and the abnormal protein in the brain of BSE cattle appear closely related. While the exact relationship between BSE and nvCJD is not fully understood, the prudent course has been to assume a possible link. This has prompted the effort to eliminate BSE in Britain (and now Europe) and to work even harder to prevent BSE from occurring in the U.S.A.

What is currently being done to prevent BSE in the U.S.A.?
In addition to importation bans on cattle and ruminant protein sources from countries with BSE, surveillance in the U.S.A. continues at a very high rate. Also, in 1997 the FDA enacted a ruminant feed ban here in the U.S.A. This prohibits feeding protein derived from mammals (such as meat and bone meal) to be fed to ruminants. There are some exceptions to this rule, but in general it is very strict and would certainly help limit any outbreak, should one occur. We have some TSEs that occur in the U.S.A. These include such diseases as scrapie in sheep, chronic wasting disease in elk and deer, and transmissible encephalopathy in mink. Monitoring of all of these TSEs is occurring, and active research is also ongoing on these conditions. There has been a large increase in the efforts to eliminate scrapie in sheep. New, more accurate diagnostic tests in sheep are being developed, and when use of these tools becomes widespread, it may be possible to completely eradicate scrapie in sheep. Currently, there is no known risk to the cattle population of the U.S.A. with regard to BSE, and there is no risk to people consuming beef products in this country. Obviously, this problem has decimated the cattle industries of the U.K. and other countries, and we must all continue to work hard to prevent this problem in the U.S.A. This disease illustrates how important research of cattle diseases is to the health of the cattle industry and to public health and confidence.

Why all the BSE reports in the press lately?
The first reason is the alarming number of new cases of BSE in European cattle. The public was led to believe that the threat of BSE spreading to Europe was very low and the spread of new cases has occurred despite the efforts in Europe. Secondly, the ban on ruminant-to-ruminant by-product feeding in the U.S.A. has been in effect since 1997, and the FDA (the agency responsible for enforcing the ban) has not been very active with regard to on-site inspections or education of feed mills relative to these regulations, according to some sources. Thus, recently, the FDA “discovered” that some meat and bone meal had inadvertently been fed to about 1,000 head of cattle in a Texas feedlot. Of course, none of that bone meal was from outside the U.S.A., and the cattle have been identified and isolated. Presently, no one has indicated that this constitutes a risk for American cattle or consumers. It may simply be the FDA responding to criticism for not doing inspections on a routine or thorough basis. It does point out the fact that industry and the regulatory agencies charged with protecting us must all work together in a coordinated manner to avoid the type of disaster that occurred in Britain and Europe.

What must we do to prevent BSE from occurring in America?
If a BSE case were to occur in the U.S.A., it would be economically and politically devastating to the cattle industry. This problem needs to be avoided, period! Stringent bans on cattle, cattle by-products, and beef products from at-risk nations need to be put into place and maintained. The regulatory agencies need to aggressively monitor these bans. Producers need to support efforts by their state and national associations to ensure that science-based policies on cattle health and food safety are implemented. This support should include volunteer efforts and membership support. The cattle industry has been very proactive on this issue. Recently, both ConAgra Beef and IBP announced they will be asking cattle producers to sign affidavits that cattle have not been fed mammalian derived protein products (such as meat and bone meal). Also, audits and inspection of feeding operations are expected as part of these new industry programs. By treating these issues seriously, U.S. producers will avoid the problems now occurring in Europe.

FOOT-AND-MOUTH DISEASE

There are no restrictions on animal movement within the state of California. We do not have Foot-and-Mouth Disease in our livestock. We are, however, always alert to foreign animal disease. Preventive measures are crucial to safeguard California's animals and economy. State and Federal programs are in place to closely monitor and regulate the movement of livestock and animal products. Despite these efforts, viruses, bacteria, and pests are capable of entering undetected on imported animals and travelers' clothing, bodies, and possessions. The illegal smuggling of animal food products also poses serious risk. The continuing cooperation of private citizens is crucial to the protection of our animal industry.

To illustrate how serious this threat can be, British officials now believe the source of the huge Foot-and-Mouth Disease (FMD) outbreak was infected meat, smuggled into England, the waste from which wound up in pig feed. An official report on the source of the outbreak also stated that the disease went undetected in sheep for up to three weeks before the first case was spotted when pigs were sent to slaughter. Officials are convinced that they are on the trail of a meat smuggling operation that could have been going on for months and are urgently verifying how waste food from Chinese restaurants was used as pigswill. The link with the Far East fits in with the strain of the virus identified in the infected livestock.

As we all know with today’s transportation system, people can easily travel throughout the world. This includes you, your friends and others who may want to visit your ranch. With that in mind, CDFA has the following recommendations for foreign travelers who may have been in countries where Foot-and-Mouth Disease has been reported.

• At Customs, declare contact with livestock and the presence of any meat or dairy products.
• Ask visitors about farm contacts and the animal disease status of countries they have recently visited.
• If possible, exclude foreign visitors from livestock facilities for at least five (5) days after arrival in the U.S.
• Do not permit clothing, shoes or other articles that have been in affected countries to enter livestock facilities.
• Provide clean protective footwear and clothing and require all visitors to thoroughly wash their hands prior to entering a livestock facility.
• Do not allow meat or animal products from FMDinfected countries to enter livestock facilities.
• Discourage close contact or handling of animals by foreign visitors.
• If traveling to an affected foreign country, carefully wash and disinfect all clothing and shoes upon your return.

  Biosecurity is the key in preventing diseases such as FMD. While biosecurity is not a term normally thought of for extensive livestock production, it certainly is in confinement operations such as poultry and swine production.

  CDFA suggests producers should consider working with their veterinarian to develop a general biosecurity plan. These recommendations go beyond what is thought to be current ranch practices, but you might give some of them consideration.

• Special emphasis should be placed on handling new additions, rodent control and monitoring, and facility and employee hygiene.
• Educate your employees about the importance of following the biosecurity plan. Provide clean coveralls, and boots for employees and visitors.
• Facilities may require that employees and visitors shower before and after their visit.
• Limit the number of visitors.
• Minimize nonessential human exposure to animals.
• Provide effective boot disinfectant solutions and brushes and dedicated protective clothing.
• Wear different overalls and boots for these visits, wash your hands frequently, and be careful not to contaminate the inside of your vehicle.
• Shower and change clothing before returning to your facility.
• If possible, do not allow trucks and vehicles to enter your facilities. If they must, make sure they are clean on arrival.
• It is not recommended that animals leaving your facility be allowed to return. However, if this occurs, isolate these returning animals as if they were new additions. The period of isolation may vary depending on the species.
• Recognize and report suspicious signs of disease to your veterinarian.
• If you learn that illegal animals or animal food products are being smuggled into the state, report it to animal health officials right away (you may remain anonymous).